Pharmacokinetic and pharmacodynamic modeling and simulation

for whom?

Users of R or S-PLUS in the bio-pharmaceutical sciences who would like to use R for clinical trial simulations.

topics include

Working with packages in R
- MASS
- deSolve

Random generation from univariate distributions
- density, distribution function, quantile function and random generation
- various distributions

Random generation from multivariate distributions
- normal distribution
- working with the covariance matrix
- simulating PK and PK-PD model parameters

Solving differential equations
- solving differential equations in R
- testing the numerical solution versus analytical solution
- PK models for single dose oral or IV administration
- PK models for multiple dose oral or IV administration
- implementing PD models

Clinical trial simulations
- combining the structural model with the random effects model
- uncertainty versus variability
- example: two compartment PK model with indirect response model


skills

Programming experience is useful.

location: Amsterdam

dates

18 March 2010, 10.00-16.30
14 October 2010, 10.00-16.30

price

EURO 395 VAT excluded

by

Dr. Jan Freijer

Jan Freijer is senior scientist at Astellas Pharma Europe and R and S-PLUS enthusiast.

All S-PLUS 8 events:
10 September 2010 Introduction to the S-Language 10.00-16.30 subscribe
22 September 2010 Introduction S-PLUS for SAS users 10.00-16.30 subscribe
14 October 2010 Pharmacokinetic and pharmacodynamic modeling and simulation 10.00-16.30 subscribe
29 October 2010 An Advanced Course on the S Language 10.00-16.30 subscribe